missing translation for 'onlineSavingsMsg'
Learn More

BAF47 Mouse, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 612111

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15816099

  • 540.00€ / 1 set
Estimated Shipment: 22-04-2024
to see stock.
Add to basket

Description

Description

SWI/SNF complexes facilitate gene activation and transcription factor binding by altering repressive chromatin structures in an ATP-dependent manner. In mammals, SWI/SNF complexes are present in mutliple forms that include 9-12 BRG1-associated factors (BAFs) per complex. These BAF proteins range in molecular weight from 47 to 250kDa. BAF47/SNF5 (SMARCB1/Ini1) complexes with BRG1- and BRM-containing SWI/SNF complexes. BAF47/SNF5 mRNA is widely expressed in cell lines and tissues, and BAF47/SNF5 gene is mutated in many human tumors. The latter is indicative of a tumor suppressor role for BAF47/SNF5. In addition, mice deficient for BAF47 die early in embryogenesis, while BAF47/SNF5 heterozygous mice display a variety of tumors in the soft tissues of the head and neck. BAF47/SNF5 also binds the HIV-1 integrase and stimulates integrase-mediated DNA joining activity. Thus, BAF47/SNF5 is a component of SWI/SNF complexes that may be critical for normal development and tumor suppression, but may also be a protein utilized for viral DNA integration into host DNA.

Western Blotting

Specifications

Specifications

BAF47
Monoclonal
250μg/mL
SNF5
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
25
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse BAF47 aa. 257-359
150 μg
Cell Biology
Human, Mouse, Rat
IgG2a
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers

For Research Use Only.